1zgu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zgu.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zgu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zgu| PDB=1zgu | SCENE= }}
{{STRUCTURE_1zgu| PDB=1zgu | SCENE= }}
-
'''Solution structure of the human Mms2-Ubiquitin complex'''
+
===Solution structure of the human Mms2-Ubiquitin complex===
-
==Overview==
+
<!--
-
Modification of proteins by post-translational covalent attachment of a single, or chain, of ubiquitin molecules serves as a signaling mechanism for a number of regulatory functions in eukaryotic cells. For example, proteins tagged with lysine-63 linked polyubiquitin chains are involved in error-free DNA repair. The catalysis of lysine-63 linked polyubiquitin chains involves the sequential activity of three enzymes (E1, E2, and E3) that ultimately transfer a ubiquitin thiolester intermediate to a protein target. The E2 responsible for catalysis of lysine-63 linked polyubiquitination is a protein heterodimer consisting of a canonical E2 known as Ubc13, and an E2-like protein, or ubiquitin conjugating enzyme variant (UEV), known as Mms2. We have determined the solution structure of the complex formed by human Mms2 and ubiquitin using high resolution, solution state nuclear magnetic resonance (NMR) spectroscopy. The structure of the Mms2-Ub complex provides important insights into the molecular basis underlying the catalysis of lysine-63 linked polyubiquitin chains.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16518696}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16518696 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16518696}}
==About this Structure==
==About this Structure==
-
1ZGU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGU OCA].
+
1ZGU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGU OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Ubiquitin binding motif]]
[[Category: Ubiquitin binding motif]]
[[Category: Uev domain]]
[[Category: Uev domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:36:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:08:25 2008''

Revision as of 09:08, 29 July 2008

Image:1zgu.png

Template:STRUCTURE 1zgu

Solution structure of the human Mms2-Ubiquitin complex

Template:ABSTRACT PUBMED 16518696

About this Structure

1ZGU is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human MMS2., Lewis MJ, Saltibus LF, Hau DD, Xiao W, Spyracopoulos L, J Biomol NMR. 2006 Feb;34(2):89-100. PMID:16518696

Page seeded by OCA on Tue Jul 29 12:08:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zgu"
Personal tools