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1quu

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[[Image:1quu.gif|left|200px]]
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{{STRUCTURE_1quu| PDB=1quu | SCENE= }}
{{STRUCTURE_1quu| PDB=1quu | SCENE= }}
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'''CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ'''
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===CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ===
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==Overview==
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We have determined the crystal structure of the two central repeats in the alpha-actinin rod at 2.5 A resolution. The repeats are connected by a helical linker and form a symmetric, antiparallel dimer in which the repeats are aligned rather than staggered. Using this structure, which reveals the structural principle that governs the architecture of alpha-actinin, we have devised a plausible model of the entire alpha-actinin rod. The electrostatic properties explain how the two alpha-actinin subunits assemble in an antiparallel fashion, placing the actin-binding sites at both ends of the rod. This molecular architecture results in a protein that is able to form cross-links between actin filaments.
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(as it appears on PubMed at http://www.pubmed.gov), where 10481917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10481917}}
==About this Structure==
==About this Structure==
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[[Category: Young, P.]]
[[Category: Young, P.]]
[[Category: Triple-helix coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:43:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:28 2008''

Revision as of 09:12, 29 July 2008

Image:1quu.png

Template:STRUCTURE 1quu

CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ

Template:ABSTRACT PUBMED 10481917

About this Structure

1QUU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments., Djinovic-Carugo K, Young P, Gautel M, Saraste M, Cell. 1999 Aug 20;98(4):537-46. PMID:10481917

Page seeded by OCA on Tue Jul 29 12:12:28 2008

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