2nww

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2nww.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2nww.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nww| PDB=2nww | SCENE= }}
{{STRUCTURE_2nww| PDB=2nww | SCENE= }}
-
'''Crystal structure of GltPh in complex with TBOA'''
+
===Crystal structure of GltPh in complex with TBOA===
-
==Overview==
+
<!--
-
Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby providing a mechanism for the concentrative uptake of substrates. Here we describe crystallographic and thermodynamic studies of Glt(Ph), a sodium (Na+)-coupled aspartate transporter, defining sites for aspartate, two sodium ions and d,l-threo-beta-benzyloxyaspartate, an inhibitor. We further show that helical hairpin 2 is the extracellular gate that controls access of substrate and ions to the internal binding sites. At least two sodium ions bind in close proximity to the substrate and these sodium-binding sites, together with the sodium-binding sites in another sodium-coupled transporter, LeuT, define an unwound alpha-helix as the central element of the ion-binding motif, a motif well suited to the binding of sodium and to participation in conformational changes that accompany ion binding and unbinding during the transport cycle.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17230192}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17230192 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17230192}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Inhibitor binding binding]]
[[Category: Inhibitor binding binding]]
[[Category: Transmembrane transporter]]
[[Category: Transmembrane transporter]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:00:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:44 2008''

Revision as of 09:12, 29 July 2008

Image:2nww.png

Template:STRUCTURE 2nww

Crystal structure of GltPh in complex with TBOA

Template:ABSTRACT PUBMED 17230192

About this Structure

2NWW is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter., Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E, Nature. 2007 Jan 25;445(7126):387-93. Epub 2007 Jan 17. PMID:17230192

Page seeded by OCA on Tue Jul 29 12:12:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nww"
Personal tools