2jm6

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[[Image:2jm6.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2jm6| PDB=2jm6 | SCENE= }}
{{STRUCTURE_2jm6| PDB=2jm6 | SCENE= }}
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'''Solution structure of MCL-1 complexed with NOXAB'''
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===Solution structure of MCL-1 complexed with NOXAB===
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==Overview==
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Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
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The line below this paragraph, {{ABSTRACT_PUBMED_17389404}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17389404 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17389404}}
==About this Structure==
==About this Structure==
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2JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
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2JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
==Reference==
==Reference==
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[[Category: Helical bundle]]
[[Category: Helical bundle]]
[[Category: Mcl-1]]
[[Category: Mcl-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:19:56 2008''

Revision as of 09:19, 29 July 2008

Image:2jm6.png

Template:STRUCTURE 2jm6

Solution structure of MCL-1 complexed with NOXAB

Template:ABSTRACT PUBMED 17389404

About this Structure

2JM6 is a Protein complex structure of sequences from Mus musculus. Full experimental information is available from OCA.

Reference

Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404

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