2bra

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{{STRUCTURE_2bra| PDB=2bra | SCENE= }}
{{STRUCTURE_2bra| PDB=2bra | SCENE= }}
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'''STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL'''
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===STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL===
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==Overview==
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During development, neurons are guided to their targets by short- and long-range attractive and repulsive cues. MICAL, a large multidomain protein, is required for the combined action of semaphorins and plexins in axon guidance. Here, we present the structure of the N-terminal region of MICAL (MICAL(fd)) determined by x-ray diffraction to 2.0 A resolution. The structure shows that MICAL(fd) is an FAD-containing module structurally similar to aromatic hydroxylases and amine oxidases. In addition, we present biochemical data that show that MICAL(fd) is a flavoenzyme that in the presence of NADPH reduces molecular oxygen to H(2)O(2) (K(m,NAPDH) = 222 microM; k(cat) = 77 sec(-1)), a molecule with known signaling properties. We propose that the H(2)O(2) produced by this reaction may be one of the signaling molecules involved in axon guidance by MICAL.
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{{ABSTRACT_PUBMED_16275926}}
==About this Structure==
==About this Structure==
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[[Category: Vesicle transport]]
[[Category: Vesicle transport]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:41:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:25:07 2008''

Revision as of 09:25, 29 July 2008

Image:2bra.png

Template:STRUCTURE 2bra

STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL

Template:ABSTRACT PUBMED 16275926

About this Structure

2BRA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and activity of the axon guidance protein MICAL., Nadella M, Bianchet MA, Gabelli SB, Barrila J, Amzel LM, Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16830-5. Epub 2005 Nov 7. PMID:16275926

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