2e2z

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{{STRUCTURE_2e2z| PDB=2e2z | SCENE= }}
{{STRUCTURE_2e2z| PDB=2e2z | SCENE= }}
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'''Solution NMR structure of yeast Tim15, co-chaperone of mitochondrial Hsp70'''
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===Solution NMR structure of yeast Tim15, co-chaperone of mitochondrial Hsp70===
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==Overview==
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Mitochondrial heat-shock protein 70 (mtHsp70) and its partner proteins drive protein import into the matrix. Tim15/Zim17/Hep1 is a mtHsp70 partner protein on the matrix side of the inner mitochondrial membrane. We determined the nuclear magnetic resonance (NMR) structure of the core domain of Tim15. On the basis of the NMR structure, we created Tim15 mutants and tested their ability to complement the functional defects of Tim15 depletion and to suppress self-aggregation of mtHsp70 in vivo. A pair of basic residues, Arg 106 and His 107, conserved Asp 111 and flexible loop 133-137, and were important (Arg 106-His 107 pair and Asp 111) or partly important (the loop 133-137) for yeast cell growth, mitochondrial protein import and the suppression of mtHsp70 aggregation. Therefore, the function of Tim15 in yeast cell growth is well correlated with its ability to suppress mtHsp70 aggregation, although it is still unknown whether inhibition of mtHsp70 aggregation is the primary function of Tim15.
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{{ABSTRACT_PUBMED_17571076}}
==About this Structure==
==About this Structure==
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2E2Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2Z OCA].
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2E2Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2Z OCA].
==Reference==
==Reference==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:27:13 2008''

Revision as of 09:27, 29 July 2008

Image:2e2z.png

Template:STRUCTURE 2e2z

Solution NMR structure of yeast Tim15, co-chaperone of mitochondrial Hsp70

Template:ABSTRACT PUBMED 17571076

About this Structure

2E2Z is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structural basis of functional cooperation of Tim15/Zim17 with yeast mitochondrial Hsp70., Momose T, Ohshima C, Maeda M, Endo T, EMBO Rep. 2007 Jul;8(7):664-70. Epub 2007 Jun 15. PMID:17571076

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