1mx3

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{{STRUCTURE_1mx3| PDB=1mx3 | SCENE= }}
{{STRUCTURE_1mx3| PDB=1mx3 | SCENE= }}
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'''Crystal structure of CtBP dehydrogenase core holo form'''
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===Crystal structure of CtBP dehydrogenase core holo form===
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==Overview==
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Transcriptional repression is based on the selective actions of recruited corepressor complexes, including those with enzymatic activities. One well-characterized developmentally important corepressor is the C-terminal binding protein (CtBP). Although intriguingly related in sequence to D2 hydroxyacid dehydrogenases, the mechanism by which CtBP functions remains unclear. We report here biochemical and crystallographic studies which reveal that CtBP is a functional dehydrogenase. In addition, both a cofactor-dependent conformational change, with NAD(+) and NADH being equivalently effective, and the active site residues are linked to the binding of the PXDLS consensus recognition motif on repressors, such as E1A and RIP140. Together, our data suggest that CtBP is an NAD(+)-regulated component of critical complexes for specific repression events in cells.
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{{ABSTRACT_PUBMED_12419229}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Transcriptional corepressor]]
[[Category: Transcriptional corepressor]]
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Revision as of 09:28, 29 July 2008

Image:1mx3.png

Template:STRUCTURE 1mx3

Crystal structure of CtBP dehydrogenase core holo form

Template:ABSTRACT PUBMED 12419229

About this Structure

1MX3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase., Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK, Mol Cell. 2002 Oct;10(4):857-69. PMID:12419229

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