2q9t

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{{STRUCTURE_2q9t| PDB=2q9t | SCENE= }}
{{STRUCTURE_2q9t| PDB=2q9t | SCENE= }}
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'''High-resolution structure of the DING protein from Pseudomonas fluorescens'''
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===High-resolution structure of the DING protein from Pseudomonas fluorescens===
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==Overview==
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A recombinant DING protein from Pseudomonas fluorescens has been previously shown to have a phosphate-binding site, and to be mitogenic for human cells. Here we report the three-dimensional structure of the protein, confirming a close similarity to the "Venus flytrap" structure seen in other human and bacterial phosphate-binding proteins. Site-directed mutagenesis confirms the role of a key residue involved in phosphate binding, and that the mitogenic activity is not dependent on this property. Deletion of one of the two hinged domains that constitute the Venus flytrap also eliminates phosphate binding whilst enhancing mitogenic activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 17612529 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17612529}}
==About this Structure==
==About this Structure==
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[[Category: Unknown function]]
[[Category: Unknown function]]
[[Category: Venus flytrap fold]]
[[Category: Venus flytrap fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:03:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:35:10 2008''

Revision as of 09:35, 29 July 2008

Image:2q9t.png

Template:STRUCTURE 2q9t

High-resolution structure of the DING protein from Pseudomonas fluorescens

Template:ABSTRACT PUBMED 17612529

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure-function relationships in a bacterial DING protein., Ahn S, Moniot S, Elias M, Chabriere E, Kim D, Scott K, FEBS Lett. 2007 Jul 24;581(18):3455-60. Epub 2007 Jun 27. PMID:17612529

Page seeded by OCA on Tue Jul 29 12:35:10 2008

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