1qk6

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[[Image:1qk6.gif|left|200px]]
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{{STRUCTURE_1qk6| PDB=1qk6 | SCENE= }}
{{STRUCTURE_1qk6| PDB=1qk6 | SCENE= }}
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'''SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR'''
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===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===
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==Overview==
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The three-dimensional structure in aqueous solution of native huwentoxin-I, a neurotoxin from the venom of the spider Selenocosmia huwena, has been determined from two-dimensional H NMR data recorded at 500 and 600 MHz. Structural constraints consisting of interproton distances inferred from NOEs and dihedral angles from spin-spin coupling constants were used as input for distance geometry calculation with the program XPLOR 3.1. The best 10 structures have NOE violations &lt; 0.3 A, dihedral violations &lt; 2 degrees, and pairwise root-mean-square differences of 1.08 (+/- 0.20) A over backbone atoms (N, C alpha, C). The molecule adopts a compact structure consisting of a small triple-stranded antiparallel beta-sheet and five beta-turns. A small hydrophobic patch consisting of Phe 6, Trp 28, and Trp 31 is located on one side of the molecule. All six lysine residues are distributed on the molecular surface. The three disulfide bridges are buried within the molecule. The structure contains an "inhibitor cystine knot motif" which is adopted by several other small proteins, such as omega-conotoxin, agatoxin IVA, and gurmarin.
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{{ABSTRACT_PUBMED_9263120}}
==About this Structure==
==About this Structure==
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1QK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].
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1QK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].
==Reference==
==Reference==
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[[Category: Spider]]
[[Category: Spider]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:22:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:38:00 2008''

Revision as of 09:38, 29 July 2008

Image:1qk6.png

Template:STRUCTURE 1qk6

SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR

Template:ABSTRACT PUBMED 9263120

About this Structure

1QK6 is a Single protein structure of sequence from Ornithoctonus huwena. Full experimental information is available from OCA.

Reference

Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution., Qu Y, Liang S, Ding J, Liu X, Zhang R, Gu X, J Protein Chem. 1997 Aug;16(6):565-74. PMID:9263120

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