2jqz

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[[Image:2jqz.jpg|left|200px]]
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[[Image:2jqz.png|left|200px]]
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{{STRUCTURE_2jqz| PDB=2jqz | SCENE= }}
{{STRUCTURE_2jqz| PDB=2jqz | SCENE= }}
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'''Solution Structure of the C2 domain of human Smurf2'''
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===Solution Structure of the C2 domain of human Smurf2===
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==Overview==
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Ubiquitination of proteins is an abundant modification that controls numerous cellular processes. Many Ubiquitin (Ub) protein ligases (E3s) target both their substrates and themselves for degradation. However, the mechanisms regulating their catalytic activity are largely unknown. The C2-WW-HECT-domain E3 Smurf2 downregulates transforming growth factor-beta (TGF-beta) signaling by targeting itself, the adaptor protein Smad7, and TGF-beta receptor kinases for degradation. Here, we demonstrate that an intramolecular interaction between the C2 and HECT domains inhibits Smurf2 activity, stabilizes Smurf2 levels in cells, and similarly inhibits certain other C2-WW-HECT-domain E3s. Using NMR analysis the C2 domain was shown to bind in the vicinity of the catalytic cysteine, where it interferes with Ub thioester formation. The HECT-binding domain of Smad7, which activates Smurf2, antagonizes this inhibitory interaction. Thus, interactions between C2 and HECT domains autoinhibit a subset of HECT-type E3s to protect them and their substrates from futile degradation in cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_17719543}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17719543 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17719543}}
==About this Structure==
==About this Structure==
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2JQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQZ OCA].
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2JQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQZ OCA].
==Reference==
==Reference==
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[[Category: Smurf2]]
[[Category: Smurf2]]
[[Category: Ubiquitin protein ligase]]
[[Category: Ubiquitin protein ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:12:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:39:09 2008''

Revision as of 09:39, 29 July 2008

Image:2jqz.png

Template:STRUCTURE 2jqz

Solution Structure of the C2 domain of human Smurf2

Template:ABSTRACT PUBMED 17719543

About this Structure

2JQZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain., Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD, Cell. 2007 Aug 24;130(4):651-62. PMID:17719543

Page seeded by OCA on Tue Jul 29 12:39:09 2008

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