1wa8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wa8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wa8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wa8| PDB=1wa8 | SCENE= }}
{{STRUCTURE_1wa8| PDB=1wa8 | SCENE= }}
-
'''SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA'''
+
===SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA===
-
==Overview==
+
<!--
-
The secreted Mycobacterium tuberculosis complex proteins CFP-10 and ESAT-6 have recently been shown to play an essential role in tuberculosis pathogenesis. We have determined the solution structure of the tight, 1:1 complex formed by CFP-10 and ESAT-6, and employed fluorescence microscopy to demonstrate specific binding of the complex to the surface of macrophage and monocyte cells. A striking feature of the complex is the long flexible arm formed by the C-terminus of CFP-10, which was found to be essential for binding to the surface of cells. The surface features of the CFP-10.ESAT-6 complex, together with observed binding to specific host cells, strongly suggest a key signalling role for the complex, in which binding to cell surface receptors leads to modulation of host cell behaviour to the advantage of the pathogen.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15973432}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15973432 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15973432}}
==About this Structure==
==About this Structure==
-
1WA8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_bovis Mycobacterium bovis] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA8 OCA].
+
1WA8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_bovis Mycobacterium bovis] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA8 OCA].
==Reference==
==Reference==
Line 41: Line 45:
[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure]]
[[Category: Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:43:09 2008''

Revision as of 09:43, 29 July 2008

Image:1wa8.png

Template:STRUCTURE 1wa8

SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA

Template:ABSTRACT PUBMED 15973432

About this Structure

1WA8 is a Protein complex structure of sequences from Mycobacterium bovis and Mycobacterium tuberculosis. Full experimental information is available from OCA.

Reference

Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6., Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD, EMBO J. 2005 Jul 20;24(14):2491-8. Epub 2005 Jun 23. PMID:15973432

Page seeded by OCA on Tue Jul 29 12:43:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wa8"
Personal tools