1nzl

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[[Image:1nzl.gif|left|200px]]
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{{STRUCTURE_1nzl| PDB=1nzl | SCENE= }}
{{STRUCTURE_1nzl| PDB=1nzl | SCENE= }}
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'''Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI'''
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===Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI===
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==Overview==
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Recruitment of the Src kinase to the activated form of the platelet-derived growth factor (PDGF) receptor involves recognition of a unique sequence motif in the juxtamembrane region of the receptor by the Src homology 2 (SH2) domain of the enzyme. This motif contains two phosphotyrosine residues separated by one residue (sequence pYIpYV where pY indicates a phosphotyrosine). Here, we provide the thermodynamic and structural basis for the binding of this motif by the Src SH2 domain. We show that the second phosphorylation event increases the free energy window for specific interaction and that the physiological target is exquisitely designed for the task of recruiting specifically an SH2 domain which otherwise demonstrates very little intrinsic ability to discriminate sequences C-terminal to the first phosphorylation event. Surprisingly, we show that water plays a role in the recognition process.
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The line below this paragraph, {{ABSTRACT_PUBMED_12706723}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12706723 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12706723}}
==About this Structure==
==About this Structure==
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[[Category: Phosphotyrosine]]
[[Category: Phosphotyrosine]]
[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:44:03 2008''

Revision as of 09:44, 29 July 2008

Image:1nzl.png

Template:STRUCTURE 1nzl

Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI

Template:ABSTRACT PUBMED 12706723

About this Structure

1NZL is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic basis for the interaction of the Src SH2 domain with the activated form of the PDGF beta-receptor., Lubman OY, Waksman G, J Mol Biol. 2003 May 2;328(3):655-68. PMID:12706723

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