1xsf

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{{STRUCTURE_1xsf| PDB=1xsf | SCENE= }}
{{STRUCTURE_1xsf| PDB=1xsf | SCENE= }}
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'''Solution structure of a resuscitation promoting factor domain from Mycobacterium tuberculosis'''
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===Solution structure of a resuscitation promoting factor domain from Mycobacterium tuberculosis===
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==Overview==
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Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis. We report the solution structure of the RPF domain from M. tuberculosis Rv1009 (RpfB) solved by heteronuclear multidimensional NMR. Structural homology with various glycoside hydrolases suggested that RpfB cleaved oligosaccharides. Biochemical studies indicate that a conserved active site glutamate is important for resuscitation activity. These data, as well as the presence of a clear binding pocket for a large molecule, indicate that oligosaccharide cleavage is probably the signal for revival from dormancy.
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{{ABSTRACT_PUBMED_15723078}}
==About this Structure==
==About this Structure==
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1XSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSF OCA].
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1XSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSF OCA].
==Reference==
==Reference==
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[[Category: Ward, J.]]
[[Category: Ward, J.]]
[[Category: Lysozyme-like structure]]
[[Category: Lysozyme-like structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:27:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:44:07 2008''

Revision as of 09:44, 29 July 2008

Image:1xsf.png

Template:STRUCTURE 1xsf

Solution structure of a resuscitation promoting factor domain from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 15723078

About this Structure

1XSF is a Single protein structure of sequence from Mycobacterium tuberculosis. Full experimental information is available from OCA.

Reference

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes., Cohen-Gonsaud M, Barthe P, Bagneris C, Henderson B, Ward J, Roumestand C, Keep NH, Nat Struct Mol Biol. 2005 Mar;12(3):270-3. Epub 2005 Feb 20. PMID:15723078

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