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1n2r

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{{STRUCTURE_1n2r| PDB=1n2r | SCENE= }}
{{STRUCTURE_1n2r| PDB=1n2r | SCENE= }}
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'''A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.'''
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===A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.===
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==Overview==
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HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by one residue on the alpha2 helix (B*4402 Asp156--&gt;B*4403 Leu156). CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes stimulate strong mutual allogeneic responses reflecting their known barrier to hemopoeitic stem cell transplantation. Although HLA-B*4402 and B*4403 share &gt;95% of their peptide repertoire, B*4403 presents more unique peptides than B*4402, consistent with the stronger T cell alloreactivity observed toward B*4403 compared with B*4402. Crystal structures of B*4402 and B*4403 show how the polymorphism at position 156 is completely buried and yet alters both the peptide and the heavy chain conformation, relaxing ligand selection by B*4403 compared with B*4402. Thus, the polymorphism between HLA-B*4402 and B*4403 modifies both peptide repertoire and T cell recognition, and is reflected in the paradoxically powerful alloreactivity that occurs across this "minimal" mismatch. The findings suggest that these closely related class I genes are maintained in diverse human populations through their differential impact on the selection of peptide ligands and the T cell repertoire.
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(as it appears on PubMed at http://www.pubmed.gov), where 12939341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12939341}}
==Disease==
==Disease==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:50:47 2008''

Revision as of 09:50, 29 July 2008

Image:1n2r.png

Template:STRUCTURE 1n2r

Contents

A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.

Template:ABSTRACT PUBMED 12939341

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1N2R is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition., Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J, J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25. PMID:12939341

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