2f66

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[[Image:2f66.gif|left|200px]]
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{{Seed}}
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[[Image:2f66.png|left|200px]]
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{{STRUCTURE_2f66| PDB=2f66 | SCENE= }}
{{STRUCTURE_2f66| PDB=2f66 | SCENE= }}
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'''Structure of the ESCRT-I endosomal trafficking complex'''
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===Structure of the ESCRT-I endosomal trafficking complex===
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==Overview==
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The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.
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The line below this paragraph, {{ABSTRACT_PUBMED_16615894}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16615894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16615894}}
==About this Structure==
==About this Structure==
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[[Category: Vps28]]
[[Category: Vps28]]
[[Category: Vps37]]
[[Category: Vps37]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:53:27 2008''

Revision as of 09:53, 29 July 2008

Image:2f66.png

Template:STRUCTURE 2f66

Structure of the ESCRT-I endosomal trafficking complex

Template:ABSTRACT PUBMED 16615894

About this Structure

2F66 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:16615894

Page seeded by OCA on Tue Jul 29 12:53:27 2008

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