2cse

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{{STRUCTURE_2cse| PDB=2cse | SCENE= }}
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'''Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution'''
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===Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution===
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==Overview==
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Reovirus is a useful model for addressing the molecular basis of membrane penetration by one of the larger nonenveloped animal viruses. We now report the structure of the reovirus virion at approximately 7.0 A resolution as obtained by electron cryomicroscopy and three-dimensional image reconstruction. Several features of the myristoylated outer capsid protein mu1, not seen in a previous X-ray crystal structure of the mu1-sigma3 heterohexamer, are evident in the virion. These features appear to be important for stabilizing the outer capsid, regulating the conformational changes in mu1 that accompany perforation of target membranes, and contributing directly to membrane penetration during cell entry.
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{{ABSTRACT_PUBMED_16216585}}
==About this Structure==
==About this Structure==
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[[Category: Membrane penetration protein]]
[[Category: Membrane penetration protein]]
[[Category: Reovirus]]
[[Category: Reovirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:56:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:54:10 2008''

Revision as of 09:54, 29 July 2008

Image:2cse.png

Template:STRUCTURE 2cse

Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution

Template:ABSTRACT PUBMED 16216585

About this Structure

2CSE is a Protein complex structure of sequences from Mammalian orthoreovirus 1 and Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.

Reference

Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution., Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS, Structure. 2005 Oct;13(10):1545-57. PMID:16216585

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