This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1owg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1owg.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1owg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1owg| PDB=1owg | SCENE= }}
{{STRUCTURE_1owg| PDB=1owg | SCENE= }}
-
'''Crystal structure of WT IHF complexed with an altered H' site (T44A)'''
+
===Crystal structure of WT IHF complexed with an altered H' site (T44A)===
-
==Overview==
+
<!--
-
Integration host factor (IHF) is a DNA-bending protein that recognizes its cognate sites through indirect readout. Previous studies have shown that binding of wild-type (WT)-IHF is disrupted by a T to A mutation at the center position of a conserved TTR motif in its binding site, and that substitution of betaGlu44 with Ala prevented IHF from discriminating between A and T at this position. We have determined the crystal structures and relative binding affinities for all combinations of WT-IHF and IHF-betaGlu44Ala bound to the WT and mutant DNAs. Comparison of these structures reveals that DNA twist plays a major role in DNA recognition by IHF, and that this geometric parameter is dependent on the dinucleotide step and not on the bound IHF variant.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12842466}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12842466 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12842466}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Minor groove]]
[[Category: Minor groove]]
[[Category: Protein-dna recognition]]
[[Category: Protein-dna recognition]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:21:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:56:53 2008''

Revision as of 09:57, 29 July 2008

Image:1owg.png

Template:STRUCTURE 1owg

Crystal structure of WT IHF complexed with an altered H' site (T44A)

Template:ABSTRACT PUBMED 12842466

About this Structure

1OWG is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Integration host factor: putting a twist on protein-DNA recognition., Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA, J Mol Biol. 2003 Jul 11;330(3):493-502. PMID:12842466

Page seeded by OCA on Tue Jul 29 12:56:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1owg"
Personal tools