1psj

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[[Image:1psj.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1psj| PDB=1psj | SCENE= }}
{{STRUCTURE_1psj| PDB=1psj | SCENE= }}
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'''ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS'''
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===ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS===
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==Overview==
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The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 8636969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8636969}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Lipid degradation]]
[[Category: Lipid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:58:11 2008''

Revision as of 09:58, 29 July 2008

Image:1psj.png

Template:STRUCTURE 1psj

ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS

Template:ABSTRACT PUBMED 8636969

About this Structure

1PSJ is a Single protein structure of sequence from Gloydius halys. Full crystallographic information is available from OCA.

Reference

Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:8636969

Page seeded by OCA on Tue Jul 29 12:58:11 2008

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