1xyh

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{{STRUCTURE_1xyh| PDB=1xyh | SCENE= }}
{{STRUCTURE_1xyh| PDB=1xyh | SCENE= }}
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'''Crystal Structure of Recombinant Human Cyclophilin J'''
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===Crystal Structure of Recombinant Human Cyclophilin J===
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==Overview==
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Cyclophilins (CyPs) are a large class of highly conserved ubiquitous peptidyl-prolyl cis-trans isomerases. CyPs have also been identified as being a specific receptor for the immunosuppressive drug cyclosporin A and are involved in a variety of biological functions. CyPJ is a novel member of the CyP family and human CyPJ (hCyPJ) is the protein encoded by a cyclophilin-like gene from human foetal brain, which shows 50% sequence identity to human cyclophilin A (hCyPA). Recombinant hCyPJ was expressed in Escherichia coli and purified. The three-dimensional structure of hCyPJ has been determined by molecular replacement using the hCyPA structure as the search model and has been refined at 2.6 angstroms resolution. The hCyPJ molecule contains four helices and one beta-barrel composed of eight antiparallel beta-strands. The overall secondary and tertiary structures of hCyPJ are similar to those of hCyPA, but hCyPJ contains an additional disulfide bridge and four segments with conformations that are strikingly different from those of hCyPA. His43 and Gln52 of hCyPJ are expected to be the active sites based on sequence alignment with hCyPA. The hCyPJ structure shows a conserved water molecule close to His43 and Gln52 which appears to support the solvent-assisted mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 15735342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15735342}}
==About this Structure==
==About this Structure==
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[[Category: Disulfide bridge]]
[[Category: Disulfide bridge]]
[[Category: Helix]]
[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:39:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:00:49 2008''

Revision as of 10:00, 29 July 2008

Image:1xyh.png

Template:STRUCTURE 1xyh

Crystal Structure of Recombinant Human Cyclophilin J

Template:ABSTRACT PUBMED 15735342

About this Structure

1XYH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family., Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):316-21. Epub 2005, Feb 24. PMID:15735342

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