1rzs

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{{STRUCTURE_1rzs| PDB=1rzs | SCENE= }}
{{STRUCTURE_1rzs| PDB=1rzs | SCENE= }}
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'''Solution structure of P22 Cro'''
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===Solution structure of P22 Cro===
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==Overview==
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We report the solution structure of the Cro protein from bacteriophage P22. Comparisons of its sequence and structure to those of lambda Cro strongly suggest an alpha-to-beta secondary structure switching event during Cro evolution. The folds of P22 Cro and lambda Cro share a three alpha helix fragment comprising the N-terminal half of the domain. However, P22 Cro's C terminus folds as two helices, while lambda Cro's folds as a beta hairpin. The all-alpha fold found for P22 Cro appears to be ancestral, since it also occurs in cI proteins, which are anciently duplicated paralogues of Cro. PSI-BLAST and transitive homology analyses strongly suggest that the sequences of P22 Cro and lambda Cro are globally homologous despite encoding different folds. The alpha+beta fold of lambda Cro therefore likely evolved from its all-alpha ancestor by homologous secondary structure switching, rather than by nonhomologous replacement of both sequence and structure.
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{{ABSTRACT_PUBMED_15062080}}
==About this Structure==
==About this Structure==
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1RZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZS OCA].
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1RZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZS OCA].
==Reference==
==Reference==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Structural evolution]]
[[Category: Structural evolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:04:02 2008''

Revision as of 10:04, 29 July 2008

Image:1rzs.png

Template:STRUCTURE 1rzs

Solution structure of P22 Cro

Template:ABSTRACT PUBMED 15062080

About this Structure

1RZS is a Single protein structure of sequence from Enterobacteria phage p22. Full experimental information is available from OCA.

Reference

Secondary structure switching in Cro protein evolution., Newlove T, Konieczka JH, Cordes MH, Structure. 2004 Apr;12(4):569-81. PMID:15062080

Page seeded by OCA on Tue Jul 29 13:04:02 2008

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