This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hc4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hc4.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2hc4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hc4| PDB=2hc4 | SCENE= }}
{{STRUCTURE_2hc4| PDB=2hc4 | SCENE= }}
-
'''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''
+
===Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol===
-
==Overview==
+
<!--
-
The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17218092}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17218092 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17218092}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
[[Category: Alpha helical sandwich]]
[[Category: Alpha helical sandwich]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:06:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:07:09 2008''

Revision as of 10:07, 29 July 2008

Image:2hc4.png

Template:STRUCTURE 2hc4

Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol

Template:ABSTRACT PUBMED 17218092

About this Structure

2HC4 is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

Reference

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092

Page seeded by OCA on Tue Jul 29 13:07:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hc4"
Personal tools