1nea

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[[Image:1nea.gif|left|200px]]
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{{STRUCTURE_1nea| PDB=1nea | SCENE= }}
{{STRUCTURE_1nea| PDB=1nea | SCENE= }}
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'''THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY'''
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===THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY===
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==Overview==
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The solution conformation of toxin alpha from Naja nigricollis (61 amino acids and four disulfides), a snake toxin which specifically blocks the activity of the nicotinic acetylcholine receptor (AcChoR), has been determined using nuclear magnetic resonance spectroscopy and molecular modeling. The solution structures were calculated using 409 distance and 73 dihedral angle restraints. The average atomic rms deviation between the eight refined structures and the mean structure is approximately 0.5 A for the backbone atoms. The overall folding of toxin alpha consists of three major loops which are stabilized by three disulfide bridges and one short C terminal loop stabilized by a fourth disulfide bridge. All the disulfides are grouped in the same region of the molecule, forming a highly constrained structure from which the loops protrude. As predicted, this structure appears to be very similar to the 1.4-A resolution crystal structure of another snake neurotoxin, namely, erabutoxin b from Laticauda semifasciata. The atomic rms deviation for the backbone atoms between the solution and crystal structures is approximately 1.7 A. The minor differences which are observed between the two structures are partly related to the deletion of one residue from the chain of toxin alpha. It is notable that, although the two toxins differ from each other by 16 amino acid substitutions, their side chains have an essentially similar spatial organization. However, most of the side chains which constitute the presumed AcChoR binding site for the curaremimetic toxins are poorly resolved in toxin alpha.(ABSTRACT TRUNCATED AT 250 WORDS)
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(as it appears on PubMed at http://www.pubmed.gov), where 1332755 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1332755}}
==About this Structure==
==About this Structure==
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1NEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEA OCA].
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1NEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEA OCA].
==Reference==
==Reference==
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[[Category: Zinn-Justin, S.]]
[[Category: Zinn-Justin, S.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:25:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:12:19 2008''

Revision as of 10:12, 29 July 2008

Image:1nea.png

Template:STRUCTURE 1nea

THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY

Template:ABSTRACT PUBMED 1332755

About this Structure

1NEA is a Single protein structure of sequence from Naja nigricollis. Full experimental information is available from OCA.

Reference

Three-dimensional solution structure of a curaremimetic toxin from Naja nigricollis venom: a proton NMR and molecular modeling study., Zinn-Justin S, Roumestand C, Gilquin B, Bontems F, Menez A, Toma F, Biochemistry. 1992 Nov 24;31(46):11335-47. PMID:1332755

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