2chg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2chg.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2chg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2chg| PDB=2chg | SCENE= }}
{{STRUCTURE_2chg| PDB=2chg | SCENE= }}
-
'''REPLICATION FACTOR C DOMAINS 1 AND 2'''
+
===REPLICATION FACTOR C DOMAINS 1 AND 2===
-
==Overview==
+
<!--
-
We have investigated the communication between subunits in replication factor C (RFC) from Archaeoglobus fulgidus. Mutation of the proposed arginine finger in the small subunits results in a complex that can still bind ATP but has impaired clamp-loading activity, a process that normally only requires binding of nucleotide. The small subunit alone forms a hexameric ring that is six-fold symmetric in the absence of ATP. However, this symmetry is broken when the nucleotide is bound to the complex. A conformational change associated with nucleotide binding may relate to the opening of PCNA rings by RFC during the loading reaction. The structures also reveal the importance of the N-terminal helix of each subunit at the ATP-binding site. Analysis of mutant protein complexes containing subunits lacking this N-terminal helix reveals key distinct regulatory roles during clamp loading that are different for the large and small subunits in the RFC complex.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16628222}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16628222 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16628222}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:09:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:15:08 2008''

Revision as of 10:15, 29 July 2008

Image:2chg.png

Template:STRUCTURE 2chg

REPLICATION FACTOR C DOMAINS 1 AND 2

Template:ABSTRACT PUBMED 16628222

About this Structure

2CHG is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Communication between subunits within an archaeal clamp-loader complex., Seybert A, Singleton MR, Cook N, Hall DR, Wigley DB, EMBO J. 2006 May 17;25(10):2209-18. Epub 2006 Apr 20. PMID:16628222

Page seeded by OCA on Tue Jul 29 13:15:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2chg"
Personal tools