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2bn5

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[[Image:2bn5.gif|left|200px]]
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{{Seed}}
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[[Image:2bn5.png|left|200px]]
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{{STRUCTURE_2bn5| PDB=2bn5 | SCENE= }}
{{STRUCTURE_2bn5| PDB=2bn5 | SCENE= }}
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'''P-ELEMENT SOMATIC INHIBITOR PROTEIN COMPLEX WITH U1-70K PROLINE-RICH PEPTIDE'''
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===P-ELEMENT SOMATIC INHIBITOR PROTEIN COMPLEX WITH U1-70K PROLINE-RICH PEPTIDE===
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==Overview==
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P-element transposition in Drosophila is regulated by tissue-specific alternative splicing of the P-element transposase pre-mRNA. In somatic cells, the P-element somatic inhibitor (PSI) protein binds to exon 3 of the pre-mRNA and recruits U1 small nuclear ribonucleoprotein (snRNP) to the F1 pseudo-splice site. This abrogates binding of U1 snRNP to the genuine 5' splice site, thereby preventing excision of the third intron. Two homologous short sequences, referred to as the A and B boxes, near the C terminus of PSI bind to U1-70k protein within U1 snRNP. We have now mapped the AB box-binding site of U1-70k to a short proline-rich sequence at the C terminus. Our NMR study shows that the B box forms an anti-parallel helical hairpin in which four highly conserved aromatic residues form a cluster on one face of the first helix. This hydrophobic cluster interacts extensively with the proline-rich region of the U1-70k protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 15990112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15990112}}
==About this Structure==
==About this Structure==
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2BN5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN5 OCA].
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2BN5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN5 OCA].
==Reference==
==Reference==
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[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Splicing]]
[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:31:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:15:12 2008''

Revision as of 10:15, 29 July 2008

Image:2bn5.png

Template:STRUCTURE 2bn5

P-ELEMENT SOMATIC INHIBITOR PROTEIN COMPLEX WITH U1-70K PROLINE-RICH PEPTIDE

Template:ABSTRACT PUBMED 15990112

About this Structure

2BN5 is a Protein complex structure of sequences from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase., Ignjatovic T, Yang JC, Butler J, Neuhaus D, Nagai K, J Mol Biol. 2005 Aug 5;351(1):52-65. PMID:15990112

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