2b3j

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{{STRUCTURE_2b3j| PDB=2b3j | SCENE= }}
{{STRUCTURE_2b3j| PDB=2b3j | SCENE= }}
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'''Crystal Structure of Staphylococcus aureus tRNA Adenosine Deaminase, TadA, in Complex with RNA'''
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===Crystal Structure of Staphylococcus aureus tRNA Adenosine Deaminase, TadA, in Complex with RNA===
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==Overview==
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Bacterial tRNA adenosine deaminases (TadAs) catalyze the hydrolytic deamination of adenosine to inosine at the wobble position of tRNA(Arg2), a process that enables this single tRNA to recognize three different arginine codons in mRNA. In addition, inosine is also introduced at the wobble position of multiple eukaryotic tRNAs. The genes encoding these deaminases are essential in bacteria and yeast, demonstrating the importance of their biological activity. Here we report the crystallization and structure determination to 2.0 A of Staphylococcus aureus TadA bound to the anticodon stem-loop of tRNA(Arg2) bearing nebularine, a non-hydrolyzable adenosine analog, at the wobble position. The cocrystal structure reveals the basis for both sequence and structure specificity in the interactions of TadA with RNA, and it additionally provides insight into the active site architecture that promotes efficient hydrolytic deamination.
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{{ABSTRACT_PUBMED_16415880}}
==About this Structure==
==About this Structure==
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[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Rna stem-loop]]
[[Category: Rna stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:48:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:16:32 2008''

Revision as of 10:16, 29 July 2008

Image:2b3j.png

Template:STRUCTURE 2b3j

Crystal Structure of Staphylococcus aureus tRNA Adenosine Deaminase, TadA, in Complex with RNA

Template:ABSTRACT PUBMED 16415880

About this Structure

2B3J is a Single protein structure of sequence from Staphylococcus aureus subsp. aureus mu50. Full crystallographic information is available from OCA.

Reference

Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA., Losey HC, Ruthenburg AJ, Verdine GL, Nat Struct Mol Biol. 2006 Feb;13(2):153-9. Epub 2006 Jan 15. PMID:16415880

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