2qkm

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{{STRUCTURE_2qkm| PDB=2qkm | SCENE= }}
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'''The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex'''
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===The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex===
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==Overview==
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A critical step in mRNA degradation is the removal of the 5' cap structure, which is catalyzed by the Dcp1-Dcp2 complex. The crystal structure of an S. pombe Dcp1p-Dcp2n complex combined with small-angle X-ray scattering analysis (SAXS) reveals that Dcp2p exists in open and closed conformations, with the closed complex being, or closely resembling, the catalytically more active form. This suggests that a conformational change between these open and closed complexes might control decapping. A bipartite RNA-binding channel containing the catalytic site and Box B motif is identified with a bound ATP located in the catalytic pocket in the closed complex, suggesting possible interactions that facilitate substrate binding. Dcp1 stimulates the activity of Dcp2 by promoting and/or stabilizing the closed complex. Notably, the interface of Dcp1 and Dcp2 is not fully conserved, explaining why the Dcp1-Dcp2 interaction in higher eukaryotes requires an additional factor.
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(as it appears on PubMed at http://www.pubmed.gov), where 18280239 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18280239}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:05:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:17:04 2008''

Revision as of 10:17, 29 July 2008

Image:2qkm.png

Template:STRUCTURE 2qkm

The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex

Template:ABSTRACT PUBMED 18280239

About this Structure

2QKM is a Protein complex structure of sequences from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structural basis of dcp2 recognition and activation by dcp1., She M, Decker CJ, Svergun DI, Round A, Chen N, Muhlrad D, Parker R, Song H, Mol Cell. 2008 Feb 15;29(3):337-49. PMID:18280239

Page seeded by OCA on Tue Jul 29 13:17:04 2008

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