2hnh

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[[Image:2hnh.gif|left|200px]]
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{{STRUCTURE_2hnh| PDB=2hnh | SCENE= }}
{{STRUCTURE_2hnh| PDB=2hnh | SCENE= }}
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'''Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III'''
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===Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III===
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==Overview==
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Bacterial replicative DNA polymerases such as Polymerase III (Pol III) share no sequence similarity with other polymerases. The crystal structure, determined at 2.3 A resolution, of a large fragment of Pol III (residues 1-917), reveals a unique chain fold with localized similarity in the catalytic domain to DNA polymerase beta and related nucleotidyltransferases. The structure of Pol III is strikingly different from those of members of the canonical DNA polymerase families, which include eukaryotic replicative polymerases, suggesting that the DNA replication machinery in bacteria arose independently. A structural element near the active site in Pol III that is not present in nucleotidyltransferases but which resembles an element at the active sites of some canonical DNA polymerases suggests that, at a more distant level, all DNA polymerases may share a common ancestor. The structure also suggests a model for interaction of Pol III with the sliding clamp and DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16959568 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16959568}}
==About this Structure==
==About this Structure==
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[[Category: Php]]
[[Category: Php]]
[[Category: Pol beta]]
[[Category: Pol beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:21:36 2008''

Revision as of 10:21, 29 July 2008

Image:2hnh.png

Template:STRUCTURE 2hnh

Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III

Template:ABSTRACT PUBMED 16959568

About this Structure

2HNH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III., Lamers MH, Georgescu RE, Lee SG, O'Donnell M, Kuriyan J, Cell. 2006 Sep 8;126(5):881-92. PMID:16959568

Page seeded by OCA on Tue Jul 29 13:21:36 2008

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