2bf0

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{{STRUCTURE_2bf0| PDB=2bf0 | SCENE= }}
{{STRUCTURE_2bf0| PDB=2bf0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE RPR OF PCF11'''
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===CRYSTAL STRUCTURE OF THE RPR OF PCF11===
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==Overview==
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The C-terminal domain (CTD) of the large subunit of RNA polymerase II is a platform for mRNA processing factors and links gene transcription to mRNA capping, splicing and polyadenylation. Pcf11, an essential component of the mRNA cleavage factor IA, contains a CTD-interaction domain that binds in a phospho-dependent manner to the heptad repeats within the RNA polymerase II CTD. We show here that the phosphorylated CTD exists as a dynamic disordered ensemble in solution and, by induced fit, it assumes a structured conformation when bound to Pcf11. In addition, we detected cis-trans populations for the CTD prolines, and found that only the all-trans form is selected for binding. These data suggest that the recognition of the CTD is regulated by independent site-specific modifications (phosphorylation and proline cis-trans isomerization) and, probably, by the local concentration of suitable binding sites.
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{{ABSTRACT_PUBMED_15665873}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:22:28 2008''

Revision as of 10:22, 29 July 2008

Image:2bf0.png

Template:STRUCTURE 2bf0

CRYSTAL STRUCTURE OF THE RPR OF PCF11

Template:ABSTRACT PUBMED 15665873

About this Structure

2BF0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD., Noble CG, Hollingworth D, Martin SR, Ennis-Adeniran V, Smerdon SJ, Kelly G, Taylor IA, Ramos A, Nat Struct Mol Biol. 2005 Feb;12(2):144-51. Epub 2005 Jan 16. PMID:15665873

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