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1ywg

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[[Image:1ywg.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ywg| PDB=1ywg | SCENE= }}
{{STRUCTURE_1ywg| PDB=1ywg | SCENE= }}
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'''The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum'''
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===The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum===
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==Overview==
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The malaria parasite Plasmodium falciparum is responsible for about two million deaths annually, making it important to obtain information about enzymes from this organism that represent potential drug targets. The gene for P. falciparum glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) has been cloned and the protein expressed as a hexahistidine-tagged recombinant protein in Escherichia coli. The recombinant protein has been crystallized and its three-dimensional structure determined. One molecule of the cofactor NAD+ is bound to each of the four subunits in the tetrameric enzyme. The major structural feature distinguishing human GAPDH from PfGAPDH is the insertion of a dipeptide (-KG-) in the so-called S loop. This insert, together with other characteristic single-amino-acid substitutions, alters the chemical environment of the groove that encompasses the R dyad and that links adjacent cofactor-binding sites and may be responsible for the selective inhibition of the enzyme by ferriprotoporphyrin IX.
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The line below this paragraph, {{ABSTRACT_PUBMED_16131754}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16131754 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16131754}}
==About this Structure==
==About this Structure==
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[[Category: Rossman fold]]
[[Category: Rossman fold]]
[[Category: Tetrameric]]
[[Category: Tetrameric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:52:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:23:06 2008''

Revision as of 10:23, 29 July 2008

Image:1ywg.png

Template:STRUCTURE 1ywg

The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum

Template:ABSTRACT PUBMED 16131754

About this Structure

1YWG is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum., Satchell JF, Malby RL, Luo CS, Adisa A, Alpyurek AE, Klonis N, Smith BJ, Tilley L, Colman PM, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1213-21. Epub 2005, Aug 16. PMID:16131754

Page seeded by OCA on Tue Jul 29 13:23:06 2008

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