2gwk

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{{STRUCTURE_2gwk| PDB=2gwk | SCENE= }}
{{STRUCTURE_2gwk| PDB=2gwk | SCENE= }}
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'''SpvB ADP-ribosylated actin: orthorhombic crystal form'''
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===SpvB ADP-ribosylated actin: orthorhombic crystal form===
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==Overview==
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Salmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal structure of the catalytic domain of SpvB, and we show by mass spectrometric analysis that SpvB modifies actin at Arg177, inhibiting its ATPase activity. We also describe two crystal structures of SpvB-modified, polymerization-deficient actin. These structures reveal that ADP-ribosylation does not lead to dramatic conformational changes in actin, suggesting a model in which this large family of toxins inhibits actin polymerization primarily through steric disruption of intrafilament contacts.
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(as it appears on PubMed at http://www.pubmed.gov), where 16905096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16905096}}
==About this Structure==
==About this Structure==
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[[Category: Actin]]
[[Category: Actin]]
[[Category: Adp-ribosylation]]
[[Category: Adp-ribosylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:37:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:21 2008''

Revision as of 10:26, 29 July 2008

Image:2gwk.png

Template:STRUCTURE 2gwk

SpvB ADP-ribosylated actin: orthorhombic crystal form

Template:ABSTRACT PUBMED 16905096

About this Structure

2GWK is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

A steric antagonism of actin polymerization by a salmonella virulence protein., Margarit SM, Davidson W, Frego L, Stebbins CE, Structure. 2006 Aug;14(8):1219-29. PMID:16905096

Page seeded by OCA on Tue Jul 29 13:26:21 2008

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