1wqy

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{{Seed}}
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{{STRUCTURE_1wqy| PDB=1wqy | SCENE= }}
{{STRUCTURE_1wqy| PDB=1wqy | SCENE= }}
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'''X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution'''
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===X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution===
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==Overview==
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It has long been suspected that the structure and function of a DNA duplex can be strongly dependent on its degree of hydration. By neutron diffraction experiments, we have succeeded in determining most of the hydrogen (H) and deuterium (D) atomic positions in the decameric d(CCATTAATGG)2 duplex. Moreover, the D positions in 27 D2O molecules have been determined. In particular, the complex water network in the minor groove has been observed in detail. By a combined structural analysis using 2.0 A resolution X-ray and 3.0 A resolution neutron data, it is clear that the spine of hydration is built up, not only by a simple hexagonal hydration pattern (as reported in earlier X-ray studies), but also by many other water bridges hydrogen-bonded to the DNA strands. The complexity of the hydration pattern in the minor groove is derived from an extraordinary variety of orientations displayed by the water molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 15914673 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15914673}}
==About this Structure==
==About this Structure==
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[[Category: Hydration]]
[[Category: Hydration]]
[[Category: Hydrogen]]
[[Category: Hydrogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:01:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:48 2008''

Revision as of 10:26, 29 July 2008

Image:1wqy.png

Template:STRUCTURE 1wqy

X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution

Template:ABSTRACT PUBMED 15914673

About this Structure

Full crystallographic information is available from OCA.

Reference

Complicated water orientations in the minor groove of the B-DNA decamer d(CCATTAATGG)2 observed by neutron diffraction measurements., Arai S, Chatake T, Ohhara T, Kurihara K, Tanaka I, Suzuki N, Fujimoto Z, Mizuno H, Niimura N, Nucleic Acids Res. 2005 May 24;33(9):3017-24. Print 2005. PMID:15914673

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