2i6z

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{{Seed}}
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{{STRUCTURE_2i6z| PDB=2i6z | SCENE= }}
{{STRUCTURE_2i6z| PDB=2i6z | SCENE= }}
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'''X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'''
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===X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme===
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==Overview==
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The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.
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(as it appears on PubMed at http://www.pubmed.gov), where 17180231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17180231}}
==About this Structure==
==About this Structure==
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[[Category: Cisplatin-lysozyme adduct]]
[[Category: Cisplatin-lysozyme adduct]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:09:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:56 2008''

Revision as of 10:26, 29 July 2008

Template:STRUCTURE 2i6z

X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Template:ABSTRACT PUBMED 17180231

About this Structure

2I6Z is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231

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