1rhp

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[[Image:1rhp.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1rhp| PDB=1rhp | SCENE= }}
{{STRUCTURE_1rhp| PDB=1rhp | SCENE= }}
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4'''
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===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4===
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==Overview==
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The crystal structure of human platelet factor 4 (PF4) has been solved to a resolution of 2.4 A by molecular replacement and refined to an R-factor of 24.1%. The structure consists of four polypeptide chains which form a tetrameric unit. N-terminal residues, previously defined as a random coil or extended loop region, form antiparallel beta-sheet-like structures that form noncovalent associations between dimers. These antiparallel beta-sheet-like structures are positioned lateral to the beta-bilayer motif and stabilize the tetrameric unit. A positively charged ring of lysine and arginine side chains encircles the PF4 tetramer sphere, presenting multiple potential sites and orientations for heparin binding. The electrostatic interactions of multiply charged amino acid side chains and hydrogen bonding interactions at the AB/CD dimer interface serve to stabilize the tetrameric structure further.
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(as it appears on PubMed at http://www.pubmed.gov), where 8031770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8031770}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
[[Category: Platelet factor]]
[[Category: Platelet factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:30:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:27:32 2008''

Revision as of 10:27, 29 July 2008

Image:1rhp.png

Template:STRUCTURE 1rhp

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4

Template:ABSTRACT PUBMED 8031770

About this Structure

1RHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human platelet factor 4., Zhang X, Chen L, Bancroft DP, Lai CK, Maione TE, Biochemistry. 1994 Jul 12;33(27):8361-6. PMID:8031770

Page seeded by OCA on Tue Jul 29 13:27:32 2008

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