1upi

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[[Image:1upi.gif|left|200px]]
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{{STRUCTURE_1upi| PDB=1upi | SCENE= }}
{{STRUCTURE_1upi| PDB=1upi | SCENE= }}
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'''MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)'''
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===MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)===
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==Overview==
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The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial cell-wall synthesis. Because it is structurally unique, highly substrate-specific and does not require a cofactor, RmlC is considered to be the most promising drug target in the pathway, and the M. tuberculosis rmlC gene was selected in the initial round of TB Structural Genomics Consortium targets for structure determination. The 1.7 A native structure determined by the consortium facilities is reported and implications for in silico screening of ligands for structure-guided drug design are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15103135 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15103135}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:28:45 2008''

Revision as of 10:28, 29 July 2008

Image:1upi.png

Template:STRUCTURE 1upi

MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)

Template:ABSTRACT PUBMED 15103135

About this Structure

1UPI is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway., Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B, Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135

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