2h1l

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{{STRUCTURE_2h1l| PDB=2h1l | SCENE= }}
{{STRUCTURE_2h1l| PDB=2h1l | SCENE= }}
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'''The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex'''
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===The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex===
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==Overview==
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The transformation potential of Simian Virus 40 depends on the activities of large T-antigen (LTag), which interacts with several cellular tumor suppressors including the important "guardian" of the genome, p53. Inhibition of p53 function by LTag is necessary for both efficient viral replication and cellular transformation. We determined the crystal structure of LTag in complex with p53. The structure reveals an unexpected hexameric complex of LTag binding six p53 monomers. Structure-guided mutagenesis of LTag and p53 residues supported the p53-LTag interface defined by the complex structure. The structure also shows that LTag binding induces dramatic conformational changes at the DNA-binding area of p53, which is achieved partially through an unusual "methionine switch" within p53. In the complex structure, LTag occupies the whole p53 DNA-binding surface and likely interferes with formation of a functional p53 tetramer. In addition, we showed that p53 inhibited LTag helicase function through direct complex formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16951253 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16951253}}
==About this Structure==
==About this Structure==
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[[Category: Lilyestrom, W.]]
[[Category: Lilyestrom, W.]]
[[Category: P53 loop-3 conformation change]]
[[Category: P53 loop-3 conformation change]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:45:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:30:33 2008''

Revision as of 10:30, 29 July 2008

Image:2h1l.png

Template:STRUCTURE 2h1l

The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex

Template:ABSTRACT PUBMED 16951253

About this Structure

2H1L is a Protein complex structure of sequences from Homo sapiens and Simian virus 40. Full crystallographic information is available from OCA.

Reference

Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor., Lilyestrom W, Klein MG, Zhang R, Joachimiak A, Chen XS, Genes Dev. 2006 Sep 1;20(17):2373-82. PMID:16951253

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