2pp4

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[[Image:2pp4.jpg|left|200px]]
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{{STRUCTURE_2pp4| PDB=2pp4 | SCENE= }}
{{STRUCTURE_2pp4| PDB=2pp4 | SCENE= }}
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'''Solution Structure of ETO-TAFH refined in explicit solvent'''
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===Solution Structure of ETO-TAFH refined in explicit solvent===
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==Overview==
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The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.
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(as it appears on PubMed at http://www.pubmed.gov), where 17572682 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17572682}}
==About this Structure==
==About this Structure==
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2PP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].
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2PP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].
==Reference==
==Reference==
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[[Category: Leukemia]]
[[Category: Leukemia]]
[[Category: Transcriptional cofactor]]
[[Category: Transcriptional cofactor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:34:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:33:03 2008''

Revision as of 10:33, 29 July 2008

Image:2pp4.png

Template:STRUCTURE 2pp4

Solution Structure of ETO-TAFH refined in explicit solvent

Template:ABSTRACT PUBMED 17572682

About this Structure

2PP4 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription., Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH, Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:17572682

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