2hld

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{{STRUCTURE_2hld| PDB=2hld | SCENE= }}
{{STRUCTURE_2hld| PDB=2hld | SCENE= }}
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'''Crystal structure of yeast mitochondrial F1-ATPase'''
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===Crystal structure of yeast mitochondrial F1-ATPase===
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==Overview==
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The crystal structure of yeast mitochondrial F(1) ATPase contains three independent copies of the complex, two of which have similar conformations while the third differs in the position of the central stalk relative to the alpha(3)beta(3) sub-assembly. All three copies display very similar asymmetric features to those observed for the bovine enzyme, but the yeast F(1) ATPase structures provide novel information. In particular, the active site that binds ADP in bovine F(1) ATPase has an ATP analog bound and therefore this structure does not represent the ADP-inhibited form. In addition, one of the complexes binds phosphate in the nucleotide-free catalytic site, and comparison with other structures provides a picture of the movement of the phosphate group during initial binding and subsequent catalysis. The shifts in position of the central stalk between two of the three copies of yeast F(1) ATPase and when these structures are compared to those of the bovine enzyme give new insight into the conformational changes that take place during rotational catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17082766 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: F1-atpase]]
[[Category: F1-atpase]]
[[Category: F1fo]]
[[Category: F1fo]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:25:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:33:41 2008''

Revision as of 10:33, 29 July 2008

Image:2hld.png

Template:STRUCTURE 2hld

Crystal structure of yeast mitochondrial F1-ATPase

Template:ABSTRACT PUBMED 17082766

About this Structure

2HLD is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase., Kabaleeswaran V, Puri N, Walker JE, Leslie AG, Mueller DM, EMBO J. 2006 Nov 15;25(22):5433-42. Epub 2006 Nov 2. PMID:17082766

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