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1ukl

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{{STRUCTURE_1ukl| PDB=1ukl | SCENE= }}
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'''Crystal structure of Importin-beta and SREBP-2 complex'''
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===Crystal structure of Importin-beta and SREBP-2 complex===
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==Overview==
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The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. We show the crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule. Importin-beta may use a similar strategy to recognize other dimeric cargoes.
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(as it appears on PubMed at http://www.pubmed.gov), where 14645851 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14645851}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear transport factor]]
[[Category: Nuclear transport factor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:21:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:30 2008''

Revision as of 10:44, 29 July 2008

Image:1ukl.png

Template:STRUCTURE 1ukl

Crystal structure of Importin-beta and SREBP-2 complex

Template:ABSTRACT PUBMED 14645851

About this Structure

1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851

Page seeded by OCA on Tue Jul 29 13:44:30 2008

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