1nyu

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[[Image:1nyu.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1nyu| PDB=1nyu | SCENE= }}
{{STRUCTURE_1nyu| PDB=1nyu | SCENE= }}
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'''Crystal Structure of Activin A Bound to the ECD of ActRIIB'''
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===Crystal Structure of Activin A Bound to the ECD of ActRIIB===
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==Overview==
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The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands that regulate cellular differentiation, proliferation, activation and apoptosis. Activins signal through complexes formed with type I and type II serine/threonine kinase receptors. We have solved the crystal structure of activin A bound to the extracellular domain of a type II receptor, ActRIIB, revealing the details of this interaction. ActRIIB binds to the outer edges of the activin finger regions, with the two receptors juxtaposed in close proximity, in a mode that differs from TGF-beta3 binding to type II receptors. The dimeric activin A structure differs from other known TGF-beta ligand structures, adopting a compact folded-back conformation. The crystal structure of the complex is consistent with recruitment of two type I receptors into a close packed arrangement at the cell surface and suggests that diversity in the conformational arrangements of TGF-beta ligand dimers could influence cellular signaling processes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12660162}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12660162 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12660162}}
==About this Structure==
==About this Structure==
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[[Category: Tgf beta]]
[[Category: Tgf beta]]
[[Category: Type ii]]
[[Category: Type ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:09:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:28 2008''

Revision as of 10:44, 29 July 2008

Image:1nyu.png

Template:STRUCTURE 1nyu

Crystal Structure of Activin A Bound to the ECD of ActRIIB

Template:ABSTRACT PUBMED 12660162

About this Structure

1NYU is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions., Thompson TB, Woodruff TK, Jardetzky TS, EMBO J. 2003 Apr 1;22(7):1555-66. PMID:12660162

Page seeded by OCA on Tue Jul 29 13:44:28 2008

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