2itd

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[[Image:2itd.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2itd| PDB=2itd | SCENE= }}
{{STRUCTURE_2itd| PDB=2itd | SCENE= }}
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'''Potassium Channel KcsA-Fab complex in Barium Chloride'''
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===Potassium Channel KcsA-Fab complex in Barium Chloride===
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==Overview==
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Thermodynamic measurements of ion binding to the Streptomyces lividans K(+) channel were carried out using isothermal titration calorimetry, whereas atomic structures of ion-bound and ion-free conformations of the channel were characterized by x-ray crystallography. Here we use these assays to show that the ion radius dependence of selectivity stems from the channel's recognition of ion size (i.e., volume) rather than charge density. Ion size recognition is a function of the channel's ability to adopt a very specific conductive structure with larger ions (K(+), Rb(+), Cs(+), and Ba(2+)) bound and not with smaller ions (Na(+), Mg(2+), and Ca(2+)). The formation of the conductive structure involves selectivity filter atoms that are in direct contact with bound ions as well as protein atoms surrounding the selectivity filter up to a distance of 15 A from the ions. We conclude that ion selectivity in a K(+) channel is a property of size-matched ion binding sites created by the protein structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 17472437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17472437}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Voltage-gated channel]]
[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:51:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:45:13 2008''

Revision as of 10:45, 29 July 2008

Image:2itd.png

Template:STRUCTURE 2itd

Potassium Channel KcsA-Fab complex in Barium Chloride

Template:ABSTRACT PUBMED 17472437

About this Structure

2ITD is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic properties of selective ion binding in a K+ channel., Lockless SW, Zhou M, MacKinnon R, PLoS Biol. 2007 May;5(5):e121. PMID:17472437

Page seeded by OCA on Tue Jul 29 13:45:13 2008

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