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225d

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{{STRUCTURE_225d| PDB=225d | SCENE= }}
{{STRUCTURE_225d| PDB=225d | SCENE= }}
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'''A TETRAMERIC DNA STRUCTURE WITH PROTONATED CYTOSINE:CYTOSINE BASE PAIRS'''
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===A TETRAMERIC DNA STRUCTURE WITH PROTONATED CYTOSINE:CYTOSINE BASE PAIRS===
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==Overview==
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Oligomers containing tracts of cytidine form hemiprotonated base pairs at acid pH and have been considered to be double-stranded. We have solved the structure of the DNA oligomer 5'-d(TCCCCC) at acid pH and find that it is a four-stranded complex in which two base-paired parallel-stranded duplexes are intimately associated, with their base pairs fully intercalated. The relative orientation of the duplexes is antiparallel, so that each base pair is face-to-face with its neighbours. The NMR spectrum displays only six spin systems, showing that the structure is highly symmetrical on the NMR timescale; the four strands are equivalent. A model derived by energy minimization and constrained molecular dynamics shows excellent compatibility with the observed nuclear Overhauser effects (NOEs) particularly for the very unusual inter-residue sugar-sugar NOEs H1'-H1', H1'-H2" and H1'-H4'. These NOEs are probably diagnostic for such tetrameric structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_8389423}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8389423 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8389423}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=225D OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=225D OCA].
==Reference==
==Reference==
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[[Category: Intercalated cytosine tetrad]]
[[Category: Intercalated cytosine tetrad]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:20:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:46:31 2008''

Revision as of 10:46, 29 July 2008

Image:225d.png

Template:STRUCTURE 225d

A TETRAMERIC DNA STRUCTURE WITH PROTONATED CYTOSINE:CYTOSINE BASE PAIRS

Template:ABSTRACT PUBMED 8389423

About this Structure

Full experimental information is available from OCA.

Reference

A tetrameric DNA structure with protonated cytosine.cytosine base pairs., Gehring K, Leroy JL, Gueron M, Nature. 1993 Jun 10;363(6429):561-5. PMID:8389423

Page seeded by OCA on Tue Jul 29 13:46:31 2008

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