28sp

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[[Image:28sp.jpg|left|200px]]
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{{STRUCTURE_28sp| PDB=28sp | SCENE= }}
{{STRUCTURE_28sp| PDB=28sp | SCENE= }}
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'''NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA'''
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===NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA===
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==Overview==
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The signal recognition particle (SRP) directs translating ribosomes to the protein translocation apparatus of endoplasmic reticulum (ER) membrane or the bacterial plasma membrane. The SRP is universally conserved, and in prokaryotes consists of two essential subunits, SRP RNA and SRP54, the latter of which binds to signal sequences on the nascent protein chains. Here we describe the solution NMR structure of a 28-mer RNA composing the most conserved part of SRP RNA to which SRP54 binds. Central to this function is a six-nucleotide internal loop that assumes a novel Mg2+-dependent structure with unusual cross-strand interactions; besides a cross-strand A/A stack, two guanines form hydrogen bonds with opposite-strand phosphates. The structure completely explains the phylogenetic conservation of the loop bases, underlining its importance for SRP54 binding and SRP function.
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(as it appears on PubMed at http://www.pubmed.gov), where 10404218 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10404218}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28SP OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28SP OCA].
==Reference==
==Reference==
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[[Category: Nmr of rna]]
[[Category: Nmr of rna]]
[[Category: Srp]]
[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:25:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:50:49 2008''

Revision as of 10:50, 29 July 2008

Image:28sp.png

Template:STRUCTURE 28sp

NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA

Template:ABSTRACT PUBMED 10404218

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the most conserved internal loop in SRP RNA., Schmitz U, James TL, Lukavsky P, Walter P, Nat Struct Biol. 1999 Jul;6(7):634-8. PMID:10404218

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