1uas

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{{STRUCTURE_1uas| PDB=1uas | SCENE= }}
{{STRUCTURE_1uas| PDB=1uas | SCENE= }}
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'''Crystal structure of rice alpha-galactosidase'''
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===Crystal structure of rice alpha-galactosidase===
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==Overview==
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alpha-Galactosidases catalyze the hydrolysis of alpha-1,6-linked galactosyl residues from galacto-oligosaccharides and polymeric galacto-(gluco)mannans. The crystal structure of rice alpha-galactosidase has been determined at 1.5A resolution using the multiple isomorphous replacement method. The structure consisted of a catalytic domain and a C-terminal domain and was essentially the same as that of alpha-N-acetylgalactosaminidase, which is the same member of glycosyl hydrolase family 27. The catalytic domain had a (beta/alpha)8-barrel structure, and the C-terminal domain was made up of eight beta-strands containing a Greek key motif. The structure was solved as a complex with d-galactose, providing a mode of substrate binding in detail. The d-galactose molecule was found bound in the active site pocket on the C-terminal side of the central beta-barrel of the catalytic domain. The d-galactose molecule consisted of a mixture of two anomers present in a ratio equal to their natural abundance. Structural comparisons of rice alpha-galactosidase with chicken alpha-N-acetylgalactosaminidase provided further understanding of the substrate recognition mechanism in these enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12657636}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12657636 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657636}}
==About this Structure==
==About this Structure==
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[[Category: Greek key motif]]
[[Category: Greek key motif]]
[[Category: Tim-barrel]]
[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:58:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:51:27 2008''

Revision as of 10:51, 29 July 2008

Image:1uas.png

Template:STRUCTURE 1uas

Crystal structure of rice alpha-galactosidase

Template:ABSTRACT PUBMED 12657636

About this Structure

1UAS is a Single protein structure of sequence from Oryza sativa. Full crystallographic information is available from OCA.

Reference

Crystal structure of rice alpha-galactosidase complexed with D-galactose., Fujimoto Z, Kaneko S, Momma M, Kobayashi H, Mizuno H, J Biol Chem. 2003 May 30;278(22):20313-8. Epub 2003 Mar 25. PMID:12657636

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