2b48

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{{STRUCTURE_2b48| PDB=2b48 | SCENE= }}
{{STRUCTURE_2b48| PDB=2b48 | SCENE= }}
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'''Bcl-XL 3D Domain Swapped Dimer'''
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===Bcl-XL 3D Domain Swapped Dimer===
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==Overview==
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Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death functions. We report the structure of a BCL-X(L) homodimers a 3D-domain swapped dimer (3DDS). The X-ray crystal structure demonstrates the mutual exchange of carboxy-terminal regions including BH2 (Bcl-2 homology 2) between monomer subunits, with the hinge region occurring at the hairpin turn between the fifth and sixth alpha helices. Both BH3 peptide-binding hydrophobic grooves are unoccupied in the 3DDS dimer and available for BH3 peptide binding, as confirmed by sedimentation velocity analysis. BCL-X(L) 3DDS dimers have increased pore-forming activity compared to monomers, suggesting that 3DDS dimers may act as intermediates in membrane pore formation. Chemical crosslinking studies of Cys-substituted BCL-X(L) proteins demonstrate that 3DDS dimers form in synthetic lipid vesicles.
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(as it appears on PubMed at http://www.pubmed.gov), where 16368107 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16368107}}
==About this Structure==
==About this Structure==
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[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Dimeric]]
[[Category: Dimeric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:49:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:52:11 2008''

Revision as of 10:52, 29 July 2008

Image:2b48.png

Template:STRUCTURE 2b48

Bcl-XL 3D Domain Swapped Dimer

Template:ABSTRACT PUBMED 16368107

About this Structure

2B48 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

BCL-XL dimerization by three-dimensional domain swapping., O'Neill JW, Manion MK, Maguire B, Hockenbery DM, J Mol Biol. 2006 Feb 17;356(2):367-81. Epub 2005 Dec 1. PMID:16368107

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