1tqy

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[[Image:1tqy.gif|left|200px]]
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{{Seed}}
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[[Image:1tqy.png|left|200px]]
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{{STRUCTURE_1tqy| PDB=1tqy | SCENE= }}
{{STRUCTURE_1tqy| PDB=1tqy | SCENE= }}
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'''The Actinorhodin Ketosynthase/Chain Length Factor'''
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===The Actinorhodin Ketosynthase/Chain Length Factor===
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==Overview==
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The synthesis of aromatic polyketides, such as actinorhodin, tetracycline and doxorubicin, begins with the formation of a polyketide chain. In type II polyketide synthases (PKSs), chains are polymerized by the heterodimeric ketosynthase-chain length factor (KS-CLF). Here we present the 2.0-A structure of the actinorhodin KS-CLF, which shows polyketides being elongated inside an amphipathic tunnel approximately 17 A in length at the heterodimer interface. The structure resolves many of the questions about the roles of KS and CLF. Although CLF regulates chain length, it does not have an active site; KS must catalyze both chain initiation and elongation. We provide evidence that the first cyclization of the polyketide occurs within the KS-CLF tunnel. The mechanistic details of this central PKS polymerase could guide biosynthetic chemists in designing new pharmaceuticals and polymers.
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The line below this paragraph, {{ABSTRACT_PUBMED_15286722}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15286722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15286722}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta-alpha-beta-alpha]]
[[Category: Alpha-beta-alpha-beta-alpha]]
[[Category: Heterodimer]]
[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:16:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:54:44 2008''

Revision as of 10:54, 29 July 2008

Image:1tqy.png

Template:STRUCTURE 1tqy

The Actinorhodin Ketosynthase/Chain Length Factor

Template:ABSTRACT PUBMED 15286722

About this Structure

1TQY is a Protein complex structure of sequences from Bacteria and Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

An antibiotic factory caught in action., Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM, Nat Struct Mol Biol. 2004 Sep;11(9):888-93. Epub 2004 Aug 1. PMID:15286722

Page seeded by OCA on Tue Jul 29 13:54:44 2008

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