1xjv

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{{STRUCTURE_1xjv| PDB=1xjv | SCENE= }}
{{STRUCTURE_1xjv| PDB=1xjv | SCENE= }}
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'''Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)'''
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===Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)===
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==Overview==
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The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the fission yeast Schizosaccharomyces pombe, and it is involved in regulation of telomere length in human cells. Here, we report the crystal structure at a resolution of 1.73 A of the N-terminal half of human POT1 (hPOT1) protein bound to a telomeric single-stranded DNA (ssDNA) decamer, TTAGGGTTAG, the minimum tight-binding sequence indicated by in vitro binding assays. The structure reveals that hPOT1 contains two oligonucleotide/ oligosaccharide-binding (OB) folds; the N-terminal OB fold binds the first six nucleotides, resembling the structure of the S. pombe Pot1pN-ssDNA complex, whereas the second OB fold binds and protects the 3' end of the ssDNA. These results provide an atomic-resolution model for chromosome end-capping.
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(as it appears on PubMed at http://www.pubmed.gov), where 15558049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15558049}}
==About this Structure==
==About this Structure==
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[[Category: Single-stranded dna]]
[[Category: Single-stranded dna]]
[[Category: Telomere]]
[[Category: Telomere]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:07:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:58:12 2008''

Revision as of 10:58, 29 July 2008

Image:1xjv.png

Template:STRUCTURE 1xjv

Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)

Template:ABSTRACT PUBMED 15558049

About this Structure

1XJV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection., Lei M, Podell ER, Cech TR, Nat Struct Mol Biol. 2004 Dec;11(12):1223-9. Epub 2004 Nov 21. PMID:15558049

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