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1w81

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[[Image:1w81.gif|left|200px]]
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{{STRUCTURE_1w81| PDB=1w81 | SCENE= }}
{{STRUCTURE_1w81| PDB=1w81 | SCENE= }}
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'''CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX'''
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===CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX===
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==Overview==
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Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15731407 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15731407}}
==About this Structure==
==About this Structure==
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[[Category: Malaria vaccine candidate]]
[[Category: Malaria vaccine candidate]]
[[Category: Plasmodium antigen]]
[[Category: Plasmodium antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:17:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:58:32 2008''

Revision as of 10:58, 29 July 2008

Image:1w81.png

Template:STRUCTURE 1w81

CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX

Template:ABSTRACT PUBMED 15731407

About this Structure

1W81 is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

Crystal structure of the malaria vaccine candidate apical membrane antigen 1., Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA, Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:15731407

Page seeded by OCA on Tue Jul 29 13:58:32 2008

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