1qqh

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[[Image:1qqh.gif|left|200px]]
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{{STRUCTURE_1qqh| PDB=1qqh | SCENE= }}
{{STRUCTURE_1qqh| PDB=1qqh | SCENE= }}
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'''2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN'''
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===2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN===
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==Overview==
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The papillomavirus E2 protein regulates viral transcription and DNA replication through interactions with cellular and viral proteins. The amino-terminal activation domain, which represents a protein class whose structural themes are poorly understood, contains key residues that mediate these functional contacts. The crystal structure of a protease-resistant core of the human papillomavirus type 18 E2 activation domain reveals a novel fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet framework. The protein surface shows extensive overlap of determinants for replication and transcription. The structure broadens the concept of activators to include proteins with potentially malleable, but certainly ordered, structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 10356398 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10356398}}
==About this Structure==
==About this Structure==
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[[Category: Amphipathic helix]]
[[Category: Amphipathic helix]]
[[Category: Cashew/kidney shape]]
[[Category: Cashew/kidney shape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:35:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:59:42 2008''

Revision as of 10:59, 29 July 2008

Image:1qqh.png

Template:STRUCTURE 1qqh

2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN

Template:ABSTRACT PUBMED 10356398

About this Structure

1QQH is a Single protein structure of sequence from Human papillomavirus type 18. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human papillomavirus type 18 E2 activation domain., Harris SF, Botchan MR, Science. 1999 Jun 4;284(5420):1673-7. PMID:10356398

Page seeded by OCA on Tue Jul 29 13:59:42 2008

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