2a5p

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[[Image:2a5p.gif|left|200px]]
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{{Seed}}
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[[Image:2a5p.png|left|200px]]
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{{STRUCTURE_2a5p| PDB=2a5p | SCENE= }}
{{STRUCTURE_2a5p| PDB=2a5p | SCENE= }}
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'''Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.'''
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===Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.===
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==Overview==
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It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.
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The line below this paragraph, {{ABSTRACT_PUBMED_16408022}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16408022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16408022}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5P OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5P OCA].
==Reference==
==Reference==
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[[Category: Monomeric parallel-stranded quadruplex]]
[[Category: Monomeric parallel-stranded quadruplex]]
[[Category: Single nucleotide chain reversal loop]]
[[Category: Single nucleotide chain reversal loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:38:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:01:24 2008''

Revision as of 11:01, 29 July 2008

Image:2a5p.png

Template:STRUCTURE 2a5p

Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.

Template:ABSTRACT PUBMED 16408022

About this Structure

Full experimental information is available from OCA.

Reference

Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter., Phan AT, Kuryavyi V, Gaw HY, Patel DJ, Nat Chem Biol. 2005 Aug;1(3):167-73. Epub 2005 Jul 17. PMID:16408022

Page seeded by OCA on Tue Jul 29 14:01:24 2008

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