2q7r

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{{STRUCTURE_2q7r| PDB=2q7r | SCENE= }}
{{STRUCTURE_2q7r| PDB=2q7r | SCENE= }}
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'''Crystal structure of human FLAP with an iodinated analog of MK-591'''
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===Crystal structure of human FLAP with an iodinated analog of MK-591===
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==Overview==
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Leukotrienes are proinflammatory products of arachidonic acid oxidation by 5-lipoxygenase that have been shown to be involved in respiratory and cardiovascular diseases. The integral membrane protein FLAP is essential for leukotriene biosynthesis. We describe the x-ray crystal structures of human FLAP in complex with two leukotriene biosynthesis inhibitors at 4.0 and 4.2 angstrom resolution, respectively. The structures show that inhibitors bind in membrane-embedded pockets of FLAP, which suggests how these inhibitors prevent arachidonic acid from binding to FLAP and subsequently being transferred to 5-lipoxygenase, thereby preventing leukotriene biosynthesis. This structural information provides a platform for the development of therapeutics for respiratory and cardiovascular diseases.
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(as it appears on PubMed at http://www.pubmed.gov), where 17600184 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17600184}}
==About this Structure==
==About this Structure==
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[[Category: Mapeg]]
[[Category: Mapeg]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:29:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:02:11 2008''

Revision as of 11:02, 29 July 2008

Image:2q7r.png

Template:STRUCTURE 2q7r

Crystal structure of human FLAP with an iodinated analog of MK-591

Template:ABSTRACT PUBMED 17600184

About this Structure

2Q7R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein., Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW, Science. 2007 Jul 27;317(5837):510-2. Epub 2007 Jun 28. PMID:17600184

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